Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study

Abstract Background Traumatic tympanic membrane (TM) perforations usually heal spontaneously. The aim of this study was to investigate whether the topical application Triticum Vulgare (TV) in experimentally induced traumatic TM rats has a positive effect on wound healing process. Methods were randomly assigned four experimental groups. Drugs introduced twice day for 7 days. On 7th day, specimens sent histological examination. Results Mean values found group NC terms epithelial regeneration mean scores are as follows: fibroblast and collagen density, neovascularization, density inflammation cells lower than all groups ( p < 0.05). It that reepithelization post-perforation better HO TV group. In subepithelial cells, fibers, formation new veins, inflammatory cell accumulation, it observed HO. Conclusion This is first investigating potential curative role an rat model perforation. Considering these findings, concluded can be more effective